• Elevated expression of Aurora A and B frequently detected

  2024-09-13

  

  Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali

• A contribution of V ATPase subunits specifically to phagosom

  2024-09-13

  

  A contribution of V-ATPase subunits specifically to phagosome-lysosome fusion was uncovered by Peri and Nüsslein-Volhard who described that depletion of the VO subunit a1 in zebrafish interferes with phagosome maturation in microglial opioid receptor (Peri and Nusslein-Volhard, 2008). However, loss

• 1027 receptor br Introduction Lung cancer is the leading

  2024-09-13

  

  Introduction Lung cancer is the leading cause of cancer death worldwide and is one of the most refractory of solid tumors along with pancreatic cancer. Since 1975 there have been notable improvements in the 5-year survival rate of patients with lung cancer [1]. This improvement in survival is tho

• Inflammations lead to the perturbation of aromatase

  2024-09-13

  

  Inflammations lead to the perturbation of aromatase enzyme [112], which normally is responsible for a broad array of critical functions. Chemotherapy targets this enzyme, so this treatment option is never side-effect-free and not fully-effective. Therefore, the mankind should be careful so as not to

• Incubation of the aortic segments of rats

  2024-09-13

  

  Incubation of the aortic segments of rats with indomethacin significantly decreased the vasoconstrictor response to Phe but only in HgCl2-treated group (Fig. 9A,B), as indicated by dAUC values (Fig. 9E). Co-treatment with losartan once again proved to be effective and prevented the increased partici

• Previous studies to investigate the functions

  2024-09-12

  

  Previous studies to investigate the functions of AHR in Treg 5402 have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the results. For example, the broad expres

• Implicit in this concept is

  2024-09-12

  

  Implicit in this concept is the idea that the β-adrenoceptors in the detrusor would be activated by adrenergic nerves of the sympathetic system: sympathetic activity promoting relaxation and enhancing bladder capacity. However, it has been demonstrated that there is only a sparse adrenergic innervat

• br Introduction Nausea and vomiting

  2024-09-12

  

  Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

• br Discussion In our current study we

  2024-09-12

  

  Discussion In our current study, we demonstrated that both the metastatic and recurrent ovarian cancer tissues expressed lower levels of p62 when compared with the patient-matched primary tumor samples. High Senegenin sale levels of p62 were associated with long progression-free survival of pati

• Cancer cells manifest characteristic abnormal growth propert

  2024-09-12

  

  Cancer Pyridoxal isonicotinoyl hydrazone sale manifest characteristic abnormal growth properties accompanying clonal evolution of cells displaying progressively increasing genomic instability capable of invasion and metastasis to distant organ sites. With the emerging knowledge about the role of kn

• The Type A series contains

  2024-09-12

  

  The Type-A series contains 6 of the 11 confirmed hits, making it a highly attractive lead template. Seven (7) out of 8 Type-A series of 3-substituted-2-furoic acids are highly active (84–100% inhibition) at the high concentration of 100μM. We could deduce some interesting, albeit preliminary structu

• br Colorectal carcinoma The growth rate of murine colon aden

  2024-09-12

  

  Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c

• Introduction Preeclampsia a serious hypertensive disorder th

  2024-09-11

  

  Introduction Preeclampsia, a serious hypertensive disorder that can occur during pregnancy, is a pregnancy-related disease characterized by the onset of 1,2-Dimyristoyl-sn-glycerol receptor and proteinuria after the 20 t h week of gestation, and it occurs in about 5% of all pregnancies [1]. If left

• The evaluation of serum electrolytes e g

  2024-09-11

  

  The evaluation of serum electrolytes (e.g.: sodium, potassium, urea, creatinine, and uric acid), liver transaminases, blood counts (e.g. identification of thrombocytopenia, and bilirubin), 24-h urine (in order to monitor proteinuria), and heart rate and lung function of the mother should be performe

• The molecular mechanisms that mediate

  2024-09-11

  

  The molecular mechanisms that mediate the plasticity of the NMJ are not well understood. PGC-1α is a master regulator of the NMJ gene expression program 23, 24, and thus AMPK might indirectly regulate the NMJ via its broad influence on the coactivator. Cerveró et al.[6] recently provided more direct

14518 records 89/968 page Previous Next First page 上5页 8687888990 下5页 Last page