• br Analytical improvements Since our review of Oxysterol Met

  2021-03-17

  

  Analytical improvements Since our review of “Oxysterol Metabolomes” in 2011 [7], there have been a number of improvements in analytical methods for the analysis of oxysterols and related compounds. McDonald and colleagues in Dallas have refined their LC-MS methods which are now applicable for ana

• Moving forward the new mathematical model opens doors for

  2021-03-17

  

  Moving forward, the new mathematical model opens doors for understanding the SCF network, where activity of a component is blunted through mutation or altered in expression in diseased states, and during therapeutic intervention. Computational modeling could reveal underappreciated secondary or tert

• Recent studies have also uncovered

  2021-03-17

  

  Recent studies have also uncovered additional roles for E2 enzymes and E2~Ub conjugates in modulating the activity of deubiquitinating enzymes (DUBs), such as OTUB1 (Juang et al., 2012, Wiener et al., 2013, Wiener et al., 2012). Interestingly, OTUB1 has also been shown to associate and modulate the

• Despite the fact that the precise relevance

  2021-03-17

  

  Despite the fact that the precise relevance of Ube2E self-ubiquitination in vivo is still elusive, findings of Sarkari et al. do establish Ube2E1 ubiquitination in bcl-xl inhibitor [36]. In vivo self-ubiquitination of Ube2E1 is further supported by the high-throughput study aimed to identify all ub

• Some family I DNA ligases

  2021-03-17

  

  Some family I DNA ligases can use dATP as nucleotide cofactor. For instance, human AZD1152-HQPA receptor I uses dATP with a catalytic efficiency that is only 36-fold lower in comparison to ATP [9]. EhDNAlig is unable to use dATP as a nucleotide cofactor, indicating a more constrained active site in

• Recently Schenck et al identified an active

  2021-03-17

  

  Recently, Schenck et al. [25] identified an active site asparagine 222 (N222) residue in the Glycine max TyrAp/PDH (GmPDH1) that is responsible for its prephenate substrate specificity. Mutating the single N222 into an acidic residue (i.e. aspartate, D) in the legume TyrAp/PDH shifted from prephenat

• We found that both DDR and DDR ECD

  2021-03-17

  

  We found that both DDR1 and DDR2 ECD increased matrix mineralization as compared to native cells, with the effect of DDR2 ECD being more prominent. Both soluble (DDR2/ECD) and membrane-bound DDR2 ECD (DDR2/-KD), when compared to wild-type cells, induced larger mineral deposits. In this regard, a rec

• br Results and Discussion br Materials

  2021-03-17

  

  Results and Discussion Materials and Methods Acknowledgements Introduction Inorganic pyrophosphate is generated as a by-product in several enzymatic reactions in cells. These reactions include DNA and RNA synthesis, activation of fatty acids and amino acids, as well as synthesis of the c

• (S)-Crizotinib br Results br Discussion br Experimental Proc

  2021-03-17

  

  Results Discussion Experimental Procedures Acknowledgments In the preceding paper, we reported 3-amido-4-anilinoquinolines as highly selective inhibitors of CSF-1R kinase, along with our initial efforts to optimize the series. Examples from the 6,7-dimethoxyquinoline series were very p

• It should be noted that not only glyphosate

  2021-03-16

  

  It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the flunixin meglumine regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2 o

• Since clinical studies mostly involved cases that

  2021-03-16

  

  Since clinical studies mostly involved cases that used MPA, data from studies that examined other types of progestogens are very limited. While the WHI study examined the combination of conjugated equine estrogens plus MPA [1], the Million Women Study [2] that also demonstrated an increased risk of

• br Physiological roles for EPAC

  2021-03-16

  

  Physiological roles for EPAC isoforms: vascular function The effects of cAMP on limiting vascular endothelial cell (VEC) inflammation and vascular smooth muscle cell (VSMC) proliferation have been well documented 36, 37, 38. However, recent work has demonstrated that several key effects of cAMP i

• br Epac in cardiovascular pathophysiology Epac orchestrates

  2021-03-16

  

  Epac in cardiovascular pathophysiology Epac orchestrates signaling actors that regulate fundamental cellular functions and general biological effects. However, some important gaps still remain in the knowledge of the physiopathological role of Epac in the heart. So far, Epac has been implicated i

• The optimization of the lead compound was

  2021-03-16

  

  The optimization of the lead compound () was initiated and the initial key SAR and the results of the structural modifications of lead compound are summarized in . Replacement of the carboxylic Darifenacin HBr moiety with other functional groups led to loss of functional activity against EP4 recepto

• br Transparency document br Acknowledgments This

  2021-03-16

  

  Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an

14082 records 633/939 page Previous Next First page 上5页 631632633634635 下5页 Last page