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In pregnancy maternal uterine spiral artery SA remodeling
2021-06-16
In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK Glycyrrhizic acid (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans
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br Introduction Pattern separation is the
2021-06-16
Introduction Pattern separation is the ability to make distinct representations from highly overlapping information, a process which is important for memory encoding (Clelland et al., 2009). For correct pattern separation, old information needs to be retrieved and compared to new information. If
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br Enzymes involved in microbial steroid degradation
2021-06-16
Enzymes involved in microbial steroid degradation are generally not expressed constitutively, but they are upregulated depending on which steroid substrates are present [17,81]. Thus, a cell-free extract prepared from testosterone-adapted C. testosteroni ATCC 11996 cells displayed a 1(2)-dehydroge
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indocid mg In summary the loss of
2021-06-16
In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to
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Injurious effects of cigarette smoke CS on human health
2021-06-16
Injurious effects of cigarette smoke (CS) on human health are progressively being acknowledged both in animal and human studies. CS is a highly complex mixture that contains substantive amounts of toxic oxidants, nitric oxide, organic compounds, free radicals and microbial cell components including
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br Author contribution br Acknowledgements QNRF grant number
2021-06-16
Author contribution Acknowledgements QNRF grant number NPRP6-065-3-012, Qatar National Research Fund, Doha Qatar for funding this work with grant number NPRP No.: NPRP6-065-3-012. Introduction Preeclampsia (PE) affects 3–5 % of pregnancies worldwide and is one of the leading causes of mate
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Though limited to a large cohort
2021-06-16
Though limited to a large cohort of self-reported healthy individuals, associations between individual Lisinopril dihydrate have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-predicted a
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Aprotinin In our opinion the precise function of AE of S
2021-06-15
In our opinion, the precise function of AE of S. mansoni (Sm32) remains unclear, and accurate knowledge of the three dimensional structure of this enzyme would be valuable for a better understanding the molecular basis of many of its properties, including its role in the host-parasite interaction, a
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inos inhibitor br RING type E s and
2021-06-15
RING-type E3s and their substrates There is enormous diversity in substrate ubiquitination and its regulation, as the targets of RING-type E3s are incredibly varied. RING-type E3s are implicated as tumor suppressors, oncogenes, and mediators of endocytosis, and play critical roles in complex mult
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br Methods for assessing TLS While the
2021-06-15
Methods for assessing TLS While the precise quantification of restricted DNA synthesis events is possible (e.g. unscheduled DNA synthesis (UDS) reveals NER), so far, it is impossible to identify TLS stretches of only a few nucleotides within the background of bulk DNA replication of normal DNA. N
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Protease Inhibitor Library sale At the cellular level TGF ha
2021-06-15
At the cellular level, TGF-β1 has been involved in the formation of invadosomes (Mandal et al., 2008, Varon et al., 2006). Invadosomes are actin-based structures involved in matrix degradation and cell invasion through metalloproteinases (MMP) activity (Linder et al., 2011). Invadosomes, constitutiv
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Bufalin A third aim of our
2021-06-15
A third aim of our investigation was to evaluate the impact of the methylation profile of p15, p16, p53, and DAPK, individually or combined, on progression-free and overall survival. We did not find any statistically significant difference in progression-free survival and overall survival in MM case
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Nevertheless two problems exist in BGCFC
2021-06-11
Nevertheless, two problems exist in BGCFC in practice. The first one is that time complexity of the ID assignment algorithm presented in Section 3.1 is O(N!), which means a factorial time complexity. Because it obtains the consecutive IDs by enumerating all permutations of ID 0 to N−1, the total num
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Introduction Safety critical systems are defined as those sy
2021-06-11
Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within
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Animal studies investigating the role of D dopamine receptor
2021-06-11
Animal studies investigating the role of D1 dopamine receptors in the PFC have focused on delayed response tasks, which require online maintenance of a previously presented stimulus. Striatal dopamine is thought to be important for flexibility and updating goal representations when new information i
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